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Determination of content of selected nonsteroidal antiphlogistic – Ibuprofen in drugs using UV/Vis and FTIR spectrometry
Lindovský, Jiří ; Sovová, Šárka (referee) ; Enev, Vojtěch (advisor)
The main aim of bachelor thesis was to validate the content of the nonsteroidal antiphlodstic in drugs using spectrometric methods and subsequent comparison of results. Specifically, the thesis is focused on Ibuprofen, which is used mainly as analgesic and antipyretic. This substance was chosen for its significant ability of absorbing electromagnetic radiation in ultraviolet and infrared regions of spectra. For this purpose, various generics were selected and analyzed by molecular absorption spectrometry (UV/Vis) and infrared spectrometry with Fourier transform (FTIR). Very important factor influencing chemometric properties of the obtained results was optimalization of the spectrometric methods. After designing the working procedure, sample solutions were prepared from Ibuprofen-containing dosage forms using suitable solvent and these samples were analyzed spectrometrically. The content of Ibuprofen in individual samples was calculated from the measured UV/Vis and FTIR spectra using method of standard addition. The results show that infrared spectrometry seems to be more suitable method for determining the Ibuprofen content. Nevertheless, it should be noted that the choice of a suitable extractant is very important step in the determination. The information obtained from this bachlor’s thesis could be used in future routine inspections and monitoring of drugs.
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Determinants of generic drug substitution in the Czech Republic
Žílová, Pavlína ; Votápková, Jana (advisor) ; Bryndová, Lucie (referee)
This study uses logistic regression to estimate the probability of choosing the brand-name drug despite the presence of cheaper generics given patient and drug characteristics in the Czech pharmaceutical market in the period 2009-2013. Results of the analysis may help guide policies to decrease pharmaceutical costs. In order to motivate people who are more likely to choose the original version of drug, policy makers may impose higher copayments and lower subsidies on the original drugs which they use. Additionally, two supplementary analyses were applied to sub-sectors of the pharmaceutical market: antihypertensive drugs and antibiotics. Fixed effects logistic regression is employed to test the robustness of the results.
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Determination of content of selected nonsteroidal antiphlogistic – Ibuprofen in drugs using UV/Vis and FTIR spectrometry
Lindovský, Jiří ; Sovová, Šárka (referee) ; Enev, Vojtěch (advisor)
The main aim of bachelor thesis was to validate the content of the nonsteroidal antiphlodstic in drugs using spectrometric methods and subsequent comparison of results. Specifically, the thesis is focused on Ibuprofen, which is used mainly as analgesic and antipyretic. This substance was chosen for its significant ability of absorbing electromagnetic radiation in ultraviolet and infrared regions of spectra. For this purpose, various generics were selected and analyzed by molecular absorption spectrometry (UV/Vis) and infrared spectrometry with Fourier transform (FTIR). Very important factor influencing chemometric properties of the obtained results was optimalization of the spectrometric methods. After designing the working procedure, sample solutions were prepared from Ibuprofen-containing dosage forms using suitable solvent and these samples were analyzed spectrometrically. The content of Ibuprofen in individual samples was calculated from the measured UV/Vis and FTIR spectra using method of standard addition. The results show that infrared spectrometry seems to be more suitable method for determining the Ibuprofen content. Nevertheless, it should be noted that the choice of a suitable extractant is very important step in the determination. The information obtained from this bachlor’s thesis could be used in future routine inspections and monitoring of drugs.
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Determinants of generic drug substitution in the Czech Republic
Žílová, Pavlína ; Votápková, Jana (advisor) ; Bryndová, Lucie (referee)
This study uses logistic regression to estimate the probability of choosing the brand-name drug despite the presence of cheaper generics given patient and drug characteristics in the Czech pharmaceutical market in the period 2009-2013. Results of the analysis may help guide policies to decrease pharmaceutical costs. In order to motivate people who are more likely to choose the original version of drug, policy makers may impose higher copayments and lower subsidies on the original drugs which they use. Additionally, two supplementary analyses were applied to sub-sectors of the pharmaceutical market: antihypertensive drugs and antibiotics. Fixed effects logistic regression is employed to test the robustness of the results.
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Business intelligence in the generic pharmaceutical industry for portfolio selection and registration strategy
Rösslerová, Petra ; Pečená, Marika (advisor) ; Papík, Richard (referee)
The aim of the diploma thesis is to describe and analyse information sources, which are useful for the molecules portfolio selection suitable for the future development of a generic drug. These information sources should be examined on the case study of the portfolio selection in a given therapeutic area. The topic of the diploma thesis is presented in the context of basic principles and functions of the generic farmaceutical industry and its information needs. The introductory chapter characterizes the farmaceutical industry in general and warn on a competitive environment, which the farmaceutical companies can succeed in thanks to the advanced methods of the business intelligence. The second chapter focuses on the differences betwen the generic and original pharmaceutical industry, a drug lifecycle is also introduced there. The next chapter specifies the methods of the business intelligence in the generic pharmaceutical industry on the ground of its information needs. The fourth chapter plays a key role. First of all, it introduces general characteristics of information sources used in the strategic portfolio management. Secondly, the detailed description and analysis of eight main information sources used by the generic companies within business intelligence follows. In the last chapter these...
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